ARG=ARGINASE INHBITOR

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Incyte is developing a first-in-class, selective arginase inhibitor.*

Arginase is an enzyme produced by immunosuppressive myeloid cells that prevents activation of effector T cells and NK cells in tumors. Arginase exerts its immunosuppressive effect by depleting the amino acid arginine in the TiME, which subsequently prevents activation and proliferation of cytotoxic T cells and NK cells. Inhibition of arginase activity reverses this immunosuppressive block and helps restore T-cell function. In preclinical models, arginase inhibition has been shown to enhance antitumor immunity and inhibit tumor growth.

*In collaboration with Calithera BioSciences, Inc.

Molecule Library
Inhibitors of JAKPI3K MoleculeFGFR InhibitorsBromodomain ProteinsPan-inhibitor of PIM kinasesLSD1 InhibitorIDO1 inhibitorSelective arginase inhibitorPD-1 antibodyGITR moleculeOX40 Agonist AntibodiesAntagonistic anti-TIM-3 antibodyLAG-3 moleculeSmall molecule inhibitor of AXL and MER

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