FIND CLINICAL TRIALS

 

GITR = GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR

 
 
 

Incyte is developing GITR agonist antibodies.

GITR is a transmembrane receptor protein expressed on effector T cells that is up-regulated during T-cell activation.

Costimulation of GITR enhances T-cell survival, increases proliferation and cytokine production, and reduces regulatory T-cell activity. As enhanced effector T-cell activity is an important component of antitumor immunity, GITR costimulation is a promising mechanism for cancer treatment.

MOLECULE LIBRARY

image show jak target.image of pi3kδ target.image of fgfr target.image of brd target.image of pim target molecule.image of lsd1 target molecule.image shows ido1 target.image shows arg target.image of pd-1 target molecule. image of gitr target molecule. image of ox40 target molecule.  image of Tim-3 target moleculeimage of Lag-3 target moleculeimage of Axr target molecule