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JAK = JANUS KINASE

 
 
 

The JAK (Janus Kinase) family of non-receptor tyrosine kinases includes JAK1, JAK2, JAK3, and TYK2.

JAKs associate with a wide variety of cytokine and growth factor receptors. On receptor activation, JAK dimers promote the phosphorylation of STATs (Signal Transducers and Activators of Transcription).

In turn, STATs regulate the downstream transcription of several target genes.

Mutations in JAK, which may lead to overactive cytokine and growth-factor signaling, have been associated with the Philadelphia-negative myeloproliferative neoplasms polycythemia vera, essential thrombocythemia, and primary myelofibrosis.

In solid tumors, signals transduced via JAK-STAT may promote a variety of biological processes considered hallmarks or enabling characteristics of cancer.

Incyte is developing inhibitors of JAK.

The JAK family of non-receptor tyrosine kinases associate with a wide variety of cytokine and growth-factor receptors.

Overactive signaling through the JAK-STAT pathway has been associated with myeloproliferative neoplasms (MPNs), and in solid tumors, signals transduced via JAK may promote a variety of biological processes considered hallmarks or enabling characteristics of cancer.

MOLECULE LIBRARY

image show jak target.image of pi3kδ target.image of fgfr target.image of brd target.image of pim target molecule.image of lsd1 target molecule.image shows ido1 target.image shows arg target.image of pd-1 target molecule. image of gitr target molecule. image of ox40 target molecule.  image of Tim-3 target moleculeimage of Lag-3 target moleculeimage of Axr target molecule