FIND CLINICAL TRIALS

 

LSD1 = LYSINE-SPECIFIC DEMETHYLASE-1

 
 
 

Incyte is developing inhibitors of LSD1.


LSD1 is an epigenetic regulator that affects gene transcription by catalyzing lysine demethylation on histone H3 and is critical for numerous cellular processes including proliferation and differentiation.


LSD1 has been implicated in liquid tumors and some solid tumors, where its overexpression likely contributes to carcinogenesis.


Downregulation or pharmacological inhibition of LSD1 expression may reduce tumor cell proliferation, restore cellular differentiation, and reduce metastatic progression in several malignancies.

MOLECULE LIBRARY

image show jak target.image of pi3kδ target.image of fgfr target.image of brd target.image of pim target molecule.image of lsd1 target molecule.image shows ido1 target.image shows arg target.image of pd-1 target molecule. image of gitr target molecule. image of ox40 target molecule.  image of Tim-3 target moleculeimage of Lag-3 target moleculeimage of Axr target molecule