Incyte is developing OX40 agonist antibodies.

OX40 is a member of the tumor necrosis factor (TNF) receptor superfamily that, when activated, may contribute to both adaptive and innate immune responses.

Part of a potent costimulatory pathway, OX40 stimulation results in increased effector T-cell survival, proliferation, and memory, and can lead to enhanced cytotoxic T-cell responses as well as inhibition of regulatory T cells. Stimulation of OX40 may promote immune-mediated antitumor activity.


image show jak target.image of pi3kδ target.image of fgfr target.image of brd target.image of pim target molecule.image of lsd1 target molecule.image shows ido1 target.image shows arg target.image of pd-1 target molecule. image of gitr target molecule. image of ox40 target molecule.  image of Tim-3 target moleculeimage of Lag-3 target moleculeimage of Axr target molecule