IDO1 = INDOLEAMINE 2,3-DIOXYGENASE 1

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Incyte is developing an IDO1 inhibitor.

IDO1 is an immunosuppressive enzyme that leads to regulatory T-cell generation and activation and allows tumors to escape from immune surveillance. Inhibition of immunomodulatory mechanisms with IDO1 inhibitor-based combination therapy may re-establish antitumor immunity.

Molecule Library
Inhibitors of JAKPI3K MoleculeFGFR InhibitorsBromodomain ProteinsPan-inhibitor of PIM kinasesLSD1 InhibitorIDO1 inhibitorSelective arginase inhibitorPD-1 antibodyGITR moleculeOX40 Agonist AntibodiesAntagonistic anti-TIM-3 antibodyLAG-3 moleculeSmall molecule inhibitor of AXL and MER

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