IDO1 = INDOLEAMINE 2,3-DIOXYGENASE 1

Incyte is developing an IDO1 inhibitor.

IDO1 is an immunosuppressive enzyme that leads to regulatory T-cell generation and activation and allows tumors to escape from immune surveillance. Inhibition of immunomodulatory mechanisms with IDO1 inhibitor-based combination therapy may re-establish antitumor immunity.