ABOUT DERMATOLOGY

Our research and development efforts in dermatology are initially focused on leveraging our knowledge of the JAK-STAT pathway. We are exploring the potential of JAK inhibition for a number of immune-mediated dermatologic conditions with a high unmet medical need, including atopic dermatitis, vitiligo, prurigo nodularis, and hidradenitis suppurativa. 

Research has shown that the JAK-STAT pathway mediates the cellular effects of cytokines involved in the pathogenesis of many immune-mediated dermatologic conditions. We strive to identify and develop therapies to modulate immune pathways driving uncontrolled inflammation to help restore normal immune function and bring the body closer to homeostasis. 

KEY DISEASES

Hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic skin condition that causes painful bumps, boils, or abscesses, often in areas with hair or where skin rubs together, like the armpits, groin, buttocks, or under the breasts. These lesions can rupture, leak, and cause scarring, with repeated outbreaks worsening over time.

Researchers are studying new treatments for HS, including an investigational oral drug called povorcitinib, a JAK1 inhibitor, and ruxolitnib cream, a topical drug inhibiting both JAK1 and JAK2. By targeting inflammatory signals in the body, povorcitinib and ruxolitnib cream aim to reduce inflammation, easing symptoms like pain, discharge, and itching while improving HS lesions.

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Prurigo nodularis

Prurigo nodularis (PN) is a long-term skin condition that causes itchy bumps called “nodules” on the skin. These nodules can appear in any part of the body, but most often appear in areas where you can scratch, such as the arms, legs, and trunk. Aside from severe itching, people with PN may also feel painful stinging and burning. These symptoms can affect a person’s quality of life. 

In these trials, researchers are investigating the use of JAK inhibitors for the treatment of PN, topical ruxolitinib cream and an oral drug called povorcitinib to determine if the treatment is effective in relieving itch and healing the nodules. 

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Vitiligo

Vitiligo is a chronic autoimmune disease where the immune system attacks melanocytes—the skin cells that produce melanin, leading to skin depigmentation. This results in white or light patches on the skin.

The condition affects 65-100 million people globally, though the actual number may be higher due to underdiagnosis. It can occur at any age, with most cases appearing before age 30. Vitiligo affects men and women equally but is slightly more common in females. It is often associated with other autoimmune diseases, particularly thyroid disorders, and can significantly impact mental health, causing anxiety, depression, and emotional challenges.

In these trials, researchers are investigating the use of JAK inhibitors for the treatment of vitiligo. Ruxolitinib cream (topical treatment) is being studied in pediatric patients and an oral drug called povorcitinib, is being studied in adult patients to determine if the treatment is effective in re-pigmentation of vitiligo lesions.

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FAQ

What is Informed Consent?
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Before you start participating in a clinical trial, you must first provide “consent”, which means you agree to participate . You will receive detailed information about the trial to help you decide. The informed consent process is designed to protect patient safety. It is designed to ensure that all potential trial participants have enough information to make an informed decision about whether or not to take part. During this process, the purpose of the clinical trial should be explained, including what your role might be, how the trial will work, as well as the benefits and risks of participation and any alternatives to the trial. You will also learn about your rights as a participant. This includes the right to decide whether or not to take part in the trial and the right to withdraw at any time, even if the trial is not complete.

How can I learn more about my condition?
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At Incyte, we are researching many conditions in our clinical trials. However, the information on this website is not a substitute for a discussion with a healthcare provider. If you decide to participate in a clinical trial, you may learn additional information about your condition, but it is important to remember that a healthcare provider is the single best source of medical advice regarding your health. Please consult a healthcare provider if you have any questions about your condition.

What is an observational study?
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An observational study collects information about you and your medical care. The focus of this type of study is on usual or routine medical care. This is the care or treatment routinely given by a doctor for a certain condition or illness.

What is the difference between a clinical trial and an observational study?
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A clinical trial is one of two main types of clinical studies. A clinical trial uses people to test out an intervention, which could be a drug, device, activity, or procedure. It is also referred to as an interventional clinical study.

The other main type of clinical study is an observational study. In an observational study, researchers observe participants on their current (or “usual”) treatment plan and track them over time to observe how they respond to a treatment. Observational studies help investigators observe and evaluate a specific question or health outcome in human participants. Participants may receive medical products such as drugs, devices, or procedures as part of their routine medical care. However, unlike in a clinical trial, the participants are not assigned to specific interventions by the investigator.

What will help me prepare for a clinical trial?
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In order to be prepared for a clinical trial, it’s important to do your own research first. Learn about as a clinical trial volunteer/participant and be sure to talk to your healthcare provider. Plan ahead and write down your questions to ask. Ask a friend or relative to come along for support and to hear responses to the questions. You should ask about the benefits and risks of the study, as well as what will be expected of you. Empowering yourself with knowledge can help you make an informed decision about whether or not a specific study is right for you.

This website provides you with an overview of the clinical trials process and allows you to search for Incyte clinical trials currently in progress.