ABOUT HEMATOLOGY AND ONCOLOGY

Even though scientists have made progress, cancer is still one of the leading causes of death worldwide1. Cancer affects millions of people, and many types of cancer don’t have enough treatment options. That’s why Incyte is working hard to research new ways to help people with cancer. 

We look at many different ways to find new treatments, including using experimental medicines on their own or combining them with other treatments to make them more effective.  

Our research focuses on understanding how cancer grows and spreads. By studying how different parts of a cell work together, we can try to find the best ways to stop cancer from growing. We also study the body’s immune system to see how we can help it fight cancer more effectively. Our teams use this knowledge to create different types of potential medicines, including small molecules and antibodies, that can be tested in clinical trials.

References: 

  1.  https://www.who.int/news-room/fact-sheets/detail/cancer 

KEY DISEASES

Myeloproliferative Neoplasms

Myeloproliferative neoplasms, or MPNs, are a group of rare, chronic blood cancers in which a person’s bone marrow does not function properly. Bone marrow is a spongy tissue inside of the bone, and is the primary place where blood cells are made. In people with MPNs there is an abnormal production of these blood cells. This can cause a host of symptoms and complications. 

A few important things to know about MPNs: 

  • MPNs are chronic conditions. Chronic conditions last for a long period of time and may never go away. 
  • MPNs are also considered to be progressive conditions, meaning that they may worsen over time. 
  • MPNs can sometimes transform into a different type of blood cancer. 
  • MPNs can affect people at any age, but they are generally more common in older adults. 

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Graft-Versus-Host-Disease

Graft-Versus-Host Disease (GVHD) is a complication of stem cell or bone marrow transplants, where donor immune cells attack the recipient's body. Symptoms vary based on the affected area. 

Acute GVHD: Typically occurs within 100 days post-transplant but can arise later. 

Chronic GVHD: Can develop months or years after the transplant. 

Incyte is conducting clinical trials to improve treatments for cGVHD, including axatilimab given alone in combination with ruxolitinib. 

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Non Hodgkin's Lymphoma

Non Hodgkin’s Lymphoma also known as NHL is a type of cancer that starts in the lymphatic system, which is part of the body's immune system1. There are many types of NHL. Incyte’s research is focusing on Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL) and Marginal Zone Lymphoma (MZL). DLBCL is the most common type of NHL and tends to grow quickly. FL and MZL both grow slowly. NHL in general affects older adults. 

Despite the progress patients and doctors have seen to date in NHL, we believe that even more can be done to improve a patients’ outcome of a disease. Incyte is focusing on evaluating individual experimental and new combinations of possible treatments which may improve and expand treatments for patients with NHL. We have multiple recruiting clinical trials to evaluate the new potential treatment options. 

References: 

  1. https://www.mayoclinic.org/diseases-conditions/non-hodgkins-lymphoma/symptoms-causes/syc-20375680

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Incyte Community

Join the Incyte Community to receive updates on news about Incyte, including information on newly enrolling trials. The Incyte Community enables you to stay informed & prepared to contribute to research you care about.

Join us in our journey as we continue to Solve On.

Join the Incyte Community

HCP Registry

Getting involved in clinical trials as an investigator enables qualified healthcare professionals with opportunities to contribute to the development and advancement of medicines.

Partner with us to become an investigator!

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FAQ

What is Informed Consent?
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Before you start participating in a clinical trial, you must first provide “consent”, which means you agree to participate . You will receive detailed information about the trial to help you decide. The informed consent process is designed to protect patient safety. It is designed to ensure that all potential trial participants have enough information to make an informed decision about whether or not to take part. During this process, the purpose of the clinical trial should be explained, including what your role might be, how the trial will work, as well as the benefits and risks of participation and any alternatives to the trial. You will also learn about your rights as a participant. This includes the right to decide whether or not to take part in the trial and the right to withdraw at any time, even if the trial is not complete.

How can I learn more about my condition?
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At Incyte, we are researching many conditions in our clinical trials. However, the information on this website is not a substitute for a discussion with a healthcare provider. If you decide to participate in a clinical trial, you may learn additional information about your condition, but it is important to remember that a healthcare provider is the single best source of medical advice regarding your health. Please consult a healthcare provider if you have any questions about your condition.

What is an observational study?
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An observational study collects information about you and your medical care. The focus of this type of study is on usual or routine medical care. This is the care or treatment routinely given by a doctor for a certain condition or illness.

What is the difference between a clinical trial and an observational study?
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A clinical trial is one of two main types of clinical studies. A clinical trial uses people to test out an intervention, which could be a drug, device, activity, or procedure. It is also referred to as an interventional clinical study.

The other main type of clinical study is an observational study. In an observational study, researchers observe participants on their current (or “usual”) treatment plan and track them over time to observe how they respond to a treatment. Observational studies help investigators observe and evaluate a specific question or health outcome in human participants. Participants may receive medical products such as drugs, devices, or procedures as part of their routine medical care. However, unlike in a clinical trial, the participants are not assigned to specific interventions by the investigator.

What will help me prepare for a clinical trial?
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In order to be prepared for a clinical trial, it’s important to do your own research first. Learn about as a clinical trial volunteer/participant and be sure to talk to your healthcare provider. Plan ahead and write down your questions to ask. Ask a friend or relative to come along for support and to hear responses to the questions. You should ask about the benefits and risks of the study, as well as what will be expected of you. Empowering yourself with knowledge can help you make an informed decision about whether or not a specific study is right for you.

This website provides you with an overview of the clinical trials process and allows you to search for Incyte clinical trials currently in progress.