Incyte's discovery strategy within the field of immunotherapy is based on the diversity of cells required to maintain an immune-suppressive microenvironment. Immune subversion by cancer cells is mediated by the action of multiple immune-regulatory cell types, and Incyte's discovery capabilities based on both small and large molecule modalities open distinct opportunities to target diverse mechanisms, including: IDO1, JAK, PI3Kδ, OX40, PD-1, and GITR.