PD-1 = PROGRAMMED CELL DEATH-1

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Incyte is developing a PD-1 antibody.

PD-1 is a protein expressed on multiple immune cells, including T cells, and acts as a key checkpoint in tumor-induced immune suppression.

Activation of PD-1 can reduce effector T-cell activity and facilitate regulatory T-cell formation, while down-regulating expression of anti-apoptotic molecules and pro-inflammatory cytokines. Blocking PD-1 can increase antitumor immunity through enhancing T-cell activity.

Molecule Library
Inhibitors of JAKPI3K MoleculeFGFR InhibitorsBromodomain ProteinsPan-inhibitor of PIM kinasesLSD1 InhibitorIDO1 inhibitorSelective arginase inhibitorPD-1 antibodyGITR moleculeOX40 Agonist AntibodiesAntagonistic anti-TIM-3 antibodyLAG-3 moleculeSmall molecule inhibitor of AXL and MER

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