PD-1 = PROGRAMMED CELL DEATH-1

Incyte is developing a PD-1 antibody.

PD-1 is a protein expressed on multiple immune cells, including T cells, and acts as a key checkpoint in tumor-induced immune suppression.

Activation of PD-1 can reduce effector T-cell activity and facilitate regulatory T-cell formation, while down-regulating expression of anti-apoptotic molecules and pro-inflammatory cytokines. Blocking PD-1 can increase antitumor immunity through enhancing T-cell activity.

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