PD-1 = PROGRAMMED CELL DEATH-1
Incyte is developing a PD-1 antibody.
PD-1 is a protein expressed on multiple immune cells, including T cells, and acts as a key checkpoint in tumor-induced immune suppression.
Activation of PD-1 can reduce effector T-cell activity and facilitate regulatory T-cell formation, while down-regulating expression of anti-apoptotic molecules and pro-inflammatory cytokines. Blocking PD-1 can increase antitumor immunity through enhancing T-cell activity.